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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NEFL All Species: 22.12
Human Site: S416 Identified Species: 54.07
UniProt: P07196 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P07196 NP_006149.2 543 61517 S416 T S G Y S Q S S Q V F G R S A
Chimpanzee Pan troglodytes Q5R1W8 466 53634 K373 Q D E I Q D M K E E M A R H L
Rhesus Macaque Macaca mulatta XP_001107100 543 61468 S416 T S G Y S Q S S Q V F G R S A
Dog Lupus familis XP_534572 544 61513 S417 T S G Y S Q S S Q V F G R S A
Cat Felis silvestris
Mouse Mus musculus P08551 543 61490 S417 T S G Y S Q S S Q V F G R S A
Rat Rattus norvegicus P19527 542 61317 S417 T S G Y S Q S S Q V F G R S A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516217 551 61697 S424 S S S Y S Q S S Q V F G R S L
Chicken Gallus gallus P16053 858 95817 Q423 G P I F T H R Q P S V T I A S
Frog Xenopus laevis P35616 544 61843 A410 T S G Y T Q S A P V F G R S A
Zebra Danio Brachydanio rerio Q58EE9 444 51231 K351 E D E I Q M L K E E M A R H L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 37.7 99.6 98.3 N.A. 95.5 95.9 N.A. 81.8 33.5 70 37.9 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 58.2 100 98.9 N.A. 97.7 98.1 N.A. 88.7 46.3 85.6 55 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. 80 0 80 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 13.3 100 100 N.A. 100 100 N.A. 86.6 26.6 93.3 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 10 0 0 0 20 0 10 60 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 20 0 0 0 10 0 0 0 0 0 0 0 0 0 % D
% Glu: 10 0 20 0 0 0 0 0 20 20 0 0 0 0 0 % E
% Phe: 0 0 0 10 0 0 0 0 0 0 70 0 0 0 0 % F
% Gly: 10 0 60 0 0 0 0 0 0 0 0 70 0 0 0 % G
% His: 0 0 0 0 0 10 0 0 0 0 0 0 0 20 0 % H
% Ile: 0 0 10 20 0 0 0 0 0 0 0 0 10 0 0 % I
% Lys: 0 0 0 0 0 0 0 20 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 30 % L
% Met: 0 0 0 0 0 10 10 0 0 0 20 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 10 0 0 0 0 0 0 20 0 0 0 0 0 0 % P
% Gln: 10 0 0 0 20 70 0 10 60 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 10 0 0 0 0 0 90 0 0 % R
% Ser: 10 70 10 0 60 0 70 60 0 10 0 0 0 70 10 % S
% Thr: 60 0 0 0 20 0 0 0 0 0 0 10 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 70 10 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 70 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _